Publications

Resolving fibrosis by stimulating HSC-dependent extracellular matrix degradation
Sharma, S., Prathigudupu, V., Cable, C., Serrano, L. R., Nerella, S., Chen, A., Hassan, G., Lakins, J., Valenzuela, C. L., Tsukui, T., Ramamoorthi, R., Kim, J. J., Willenbring, H., Mattis, A. N., Volk, R. F., Zaro, B. W., Coon, J. J., Beresis, R., DeGrado, W. F., Weaver, V. M., Christenson, S. A., Jo, H., & Chen, J. Y. (2025). Science Translational Medicine, 17(813), eads9470. https://doi.org/10.1126/scitranslmed.ads9470

Exploration of a Class of Aryl Imidazolyl Ureas As Potent Acid Ceramidase Inhibitors for the Treatment of Fibrotic Diseases
Beresis, R., Prathigudupu, V., Cable, C., Yu, A., Adler, M., Ramamoorthi, R., Yeon, S. K., Gordan, J. D., Sharma, S., DeGrado, W. F., Zaro, B., Chen, J. Y., & Jo, H. (2025). ACS Omega, 10(31), 34747–34761. https://doi.org/10.1021/acsomega.5c03734

AMPK stimulation inhibits YAP/TAZ signaling to ameliorate hepatic fibrosis
Shihan, M. H., Sharma, S., Cable, C., Prathigudupu, V., Chen, A., Mattis, A. N., & Chen, J. Y. (2024). Scientific Reports, 14(1), 5205. https://doi.org/10.1038/s41598-024-55764-5

Cellular stress in the pathogenesis of nonalcoholic steatohepatitis and liver fibrosis
Sharma, S., Le Guillou, D., & Chen, J. Y. (2023). Nature Reviews Gastroenterology & Hepatology, 20(10), 662–678. https://doi.org/10.1038/s41575-023-00832-w

Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells
Li, W., Chen, J. Y., Sun, C., Sparks, R. P., Pantano, L., Rahman, R.-U., Moran, S. P., Pondick, J. V., Kirchner, R., Wrobel, D., Bieler, M., Sauer, A., Ho Sui, S. J., Doerner, J. F., Rippmann, J. F., & Mullen, A. C. (2022). eLife, 11. https://doi.org/10.7554/eLife.74513

Targeting acid ceramidase ameliorates fibrosis in mouse models of non‑alcoholic steatohepatitis
Yu, A., Cable, C., Sharma, S., Shihan, M. H., Mattis, A. N., Mileva, I., Hannun, Y. A., Duwaerts, C. C., & Chen, J. Y. (2022). Frontiers in Medicine (Lausanne), 9, 881848. https://doi.org/10.3389/fmed.2022.881848

Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice
Alsamman, S., Christenson, S. A., Yu, A., Ayad, N. M. E., Mooring, M. S., Segal, J. M., Hu, J. K.-H., Schaub, J. R., Ho, S. S., Rao, V., Marlow, M. M., Turner, S. M., Sedki, M., Pantano, L., Ghoshal, S., Ferreira, D. D. S., Ma, H.-Y., Duwaerts, C. C., Espanol-Suner, R., Wei, L., Newcomb, B., Mileva, I., Canals, D., Hannun, Y. A., Chung, R. T., Mattis, A. N., Fuchs, B. C., Tager, A. M., Yimlamai, D., Weaver, V. M., Mullen, A. C., Sheppard, D., & Chen, J. Y. (2020). Science Translational Medicine, 12, 557. https://doi.org/10.1126/scitranslmed.aay8798

Tricyclic Antidepressants Promote Ceramide Accumulation to Regulate Collagen Production in Human Hepatic Stellate Cells
Chen, J. Y., Newcomb, B., Zhou, C., Pondick, J. V., Ghoshal, S., York, S. R., Motola, D. L., Coant, N., Yi, J. K., Mao, C., Tanabe, K. K., Bronova, I., Berdyshev, E. V., Fuchs, B. C., Hannun, Y., Chung, R. T., & Mullen, A. C. (2017). Scientific Reports, 7, 44867. https://doi.org/10.1038/srep44867

Long noncoding RNAs expressed in human hepatic stellate cells form networks with extracellular matrix proteins
Zhou, C., York, S. R., Chen, J. Y., Pondick, J. V., Motola, D. L., Chung, R. T., & Mullen, A. C. (2016). Genome Medicine, 8(1), 31. https://doi.org/10.1186/s13073-016-0285-0

HCV and HIV co-infection: mechanisms and management
Chen, J. Y., Feeney, E. R., & Chung, R. T. (2014). Nature Reviews Gastroenterology & Hepatology, 11(6), 362–371. https://doi.org/10.1038/nrgastro.2014.17